Mutation profile in BCR-ABL1-negative myeloproliferative neoplasms: A single-center experience from India
نویسندگان
چکیده
منابع مشابه
Second malignancies in philadelphia-negative myeloproliferative neoplasms-single-center experience.
AIM The aim of this work was to retrospectively analyze patients with Philadelphia-negative myeloproliferative neoplasms through evaluation of frequency and characteristics of second malignancies (other than acute leukaemia and myelodysplastic syndrome). PATIENTS AND METHODS Records of 172 patients were reviewed; an analysis was performed on data from 66 patients treated with hydroxyurea, 105...
متن کاملMyeloproliferative Disorders BCR-ABL1—Negative Myeloproliferative Neoplasms: A Review of Molecular Biology, Diagnosis, and Treatment
In 2008, the World Health Organization expanded the classification of myeloproliferative disorders based on increasing amounts of molecular and cytogenetic data. Myeloproliferative neoplasms (MPN) that do not contain the BCR-ABL1 mutation include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). JAK2V617F is the best characterized mutation in BCR-ABL1–nega...
متن کاملCurrent pre-clinical and clinical advances in the BCR-ABL1-positive and -negative chronic myeloproliferative neoplasms.
Immunosenescence is an ill-defined term commonly used to describe the differences observed between younger and older individuals in a broad range of immune parameters. Humans and mice are the best-studied, but indications of immunosenescence have also been reported in primates, dogs, cats and horses. Although often referred to as age-associated changes to immunity, and almost always assumed to ...
متن کاملComparative study of different methodologies to detect the JAK2 V617F mutation in chronic BCR-ABL1 negative myeloproliferative neoplasms
OBJECTIVES A mutation in the JAK2 gene, V617F, has been identified in several BCR-ABL1 negative myeloproliferative neoplasms (MPN): polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Defining the presence or absence of this mutation is an essential part of clinical diagnostic algorithms and patient management. Here, we aimed to evaluate the performance of t...
متن کاملAllelic Expression Imbalance of JAK2 V617F Mutation in BCR-ABL Negative Myeloproliferative Neoplasms
The discovery of a single point mutation in the JAK2 gene in patients with BCR/ABL-negative myeloproliferative neoplasms (MPNs) has not only brought new insights and pathogenesis, but also has made the diagnosis of MPNs much easier. Although, to date, several mechanisms for the contribution of single JAK2V617F point mutation to phenotypic diversity of MPNs have been suggested in multiple studie...
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ژورنال
عنوان ژورنال: Hematology/Oncology and Stem Cell Therapy
سال: 2021
ISSN: 1658-3876
DOI: 10.1016/j.hemonc.2021.03.002